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NTx Bio Cryo-EM Services

Accelerate Your Research with New Mexico’s only high-end Cryo-Electron Microscopy (Cryo-EM) facility

Unlock high-resolution insights with our expert cryo-EM team and streamlined, project-ready service packages. Whether you're evaluating sample quality or capturing millions of particles for high-resolution structure determination, we help you generate high-quality data, fast.

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READY TO GET STARTED?

Whether you're new to cryo-EM or looking to expand your current capabilities, our team is here to help. Reach out to discuss your project needs, turnaround times, or to get a custom quote. Click the button below to get started.

 
Tell Us About Your Sample
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Our Cryo-EM Facility

Sample Preparation Suite

Our humidity-controlled clean room is equipped with state-of-the-art tools to ensure reproducible and high-quality sample prep:

Vitrobot Mark IV™ – Automated vitrification for consistent plunge freezing
PELCO easiGlow™ – Glow discharge system for EM grid surface preparation
Cryo-EM Grid Clipping Station – For clipping grids into autoloader-compatible cartridges
Autoloader Cassette Transfer Station – Enables secure loading of autogrids into microscopes

 

Microscopy Platform

Thermo Fisher Glacios 2 Cryo-TEM (200 kV)
Equipped with:
Falcon 4i  Direct Electron Detector for high-resolution imaging
Autoloader system for efficient, automated grid handling
Spicer SC24 magnetic field canceling system
Mounted on an anti-vibration floating slab to ensure optimal image quality

 

Data Acquisition & Processing

We use industry-leading software to streamline alignment, data capture, and image processing:

EPU – Automated data collection
MiCo – Microscope alignment and control
Relion or CryoSPARC– Image processing and data management
Service What We Offer
Sample Optimization 

Grid preparation, screening, preliminary imaging and storage/return
Image Acquisition  Automated data collection (>=50  images)
Data Processing & 3D Analysis 
 SPA workflows, cryo-EM map generation, atomic modeling, conformational flexibility analysis
Training Hands-on sessions with Vitrobot, Glacios, and EPU for grid preparation screening, and SPA setup
Consulting Project design strategy, sample suitability, optimization advice, and publication-ready visuals

 

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Our Team Has The Right Experience For Your Success

Our team members, Dr. Andrea Vaiana and Dr. Cristina Iancu, have a combined experience in cryo-EM of over 15 years. They worked with a variety of biological samples including proteins (varying in size from 70 KDa to 13 MDa), liposomes, lipid nanoparticles, virus-like particles, organelle-like particles, and whole bacterial cells.

 

See Relevant Cryo-EM Publications below

Relevant Cryo-EM Publications