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title: NTxpress
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# Pure, Scalable Protein Synthesis. On Demand.

## Fully Recombinant *In Vitro* Protein Manufacturing

Introducing **NTxpress®**—the future platform for cell-free protein synthesis. Leveraging a fully recombinant system, **NTxpress®** is designed to deliver high-yield, high-purity proteins with speed and scalability, free from the limitations of traditional cell-based or extract-based methods. NTx has developed a fully recombinant, thermostable, reliable, and functional in vitro transcription/translation system for the production of biologics.

### First and only fully recombinant cell-free expression system to produce proteins and minimize unwanted cellular metabolism

**Extract-based *in vitro* systems are challenged by:**

- Residual metabolic activity lowering efficiency (nucleotide and amino acid recycling)
- Presence of cellular nucleases that degrade input DNA
- Proteases that degrade target protein
- Poor reproducibility

### The NTxpress® Advantage: Purely Recombinant Technology

#### Extract-Based Cell-Free Expression

- Cell extracts from E. coli, wheat germ, rabbit reticulocyte, insect cells
- Mostly circular DNA templates
- Energy regeneration based upon ATP present in lysate
- Limited run times
- Poor reproducibility

#### NTx Cell-Free Expression

- Minimize unwanted cellular metabolism
- Supports linear or circular DNA templates
- Efficient ATP regenerating system to supply sustained energy
- High reproducibility
- Generate target proteins in less than a day

### Streamlined, Scalable Protein Production

In comparison to cell-based expression, cell-free (CF) production of biologics offers **enhanced flexibility, quicker response times, reduced energy consumption, and a smaller facility footprint.** CF production does not require dedicated facilities per strain/product and can be scaled throughout the commercialization process **saving time and money**.

**NTxpress**® is designed to offer high-quality linear scaling with compressed cycle time for product manufacturing. The **NTxpress**® platform requires limited upfront capital investment and can be adapted for a turnkey modular solution.

#### Creating the fast lane for vital therapeutics.

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NTx is enabling the future of medicine with cell-free biomanufacturing systems that drive breakthroughs in research, therapeutics, and personalized cancer vaccines. The company’s flagship NTxscribe platform brings industrial-grade RNA manufacturing to the benchtop, producing high-purity, high-integrity RNA with unmatched speed, efficiency, and scalability – all within a fully closed system. NTxscribe’s single-use RNA cartridges run on NTxbiomaterials, a proprietary line of reagents that are manufactured in the U.S. with fully domestic raw materials.

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